Capecitabine pharmacokinetics and toxicity

Nov 20, 2019 · Capecitabine, dFCR, and FBAL pharmacokinetics were well described by two‐compartment models, and dFUR and 5‐FU were subject to flip‐flop pharmacokinetics. Retrospective analyses however Although the main mechanism of 5-FU cytotoxicity was thought to be attributed to DNA damages, recent reports have shown that the majority of 5-FU pharmacological action is mediated through RNA, since 5-FU is accumulated ~3000- to 15 000-fold more in RNA compared to that of DNA

2024-03-29
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  8. The average total daily dose was 1265 ± 350 mg/m 2 /day