This enzyme changes testosterone to another hormone that causes the prostate to grow
A topical formulation of finasteride has been
Finasteride / therapeutic use Prostatic Hyperplasia / blood Prostatic Hyperplasia / drug therapy* Prostatic Hyperplasia / pathology Sexual Dysfunction, Physiological / chemically
Finasteride is known to inhibit Type 2 5α-reductase and thus block the conversion of testosterone to dihydrotestosterone (DHT)
Finasteride is a selective inhibitor of 5α-reductase 2, one isozyme of 5α-reductase found in abundance in the human prostate
This connection between testosterone and cardiovascular diseases led the team to explore finasteride's potential impact beyond
, in hepatocytes), which have well-developed endoplasmic reticulum (ERet)
Finasteride is a 5α-reductase enzyme inhibitor that has been approved for the treatment of male androgenic alopecia since 1997
These include gynecomastia (enlarged breasts in men), increased body fat levels and sexual problems
Sex hormones influence the prevalence and the outcome of heart diseases
It will increase testosterone levels in the body, which decreases prostate size
An androgen-dependent prostate cancer cell line (LNCaP) was cultured in charcoal/dextran-treated FBS with DHT or testosterone, and treated with finasteride for 1–3 weeks
Finasteride blocks the metabolism of testosterone
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[28] Finasteride 1mg daily (Propecia) is approved for male pattern baldness, while the 5mg daily dose (Proscar) is approved for management of prostatic hypertrophy
Patients should be advised to stop finasteride Propecia prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body
The structural similarity of finasteride to DHT raises the possibility that finasteride may also interfere with the function of the androgen receptor (AR)
Finasteride administration significantly downregulated androgen receptors (ARs) in the lacrimal gland the significance observed with tear film break up time (TBUT) and tear flow could be attributed to the lack of 5α-DHT in the lacrimal glands [20,23]
These complications Androgen receptor splice variants, such as AR-V7 commonly occur in clinical specimens, and approximately 75% of described to date including full length AR as well as ligand-independent splice variants
Traditionally, topical minoxidil and oral finasteride have been the standard of care yielding mixed results